Preparation and Characterization of Fe3O4 Magnetic Nanoparticles Labeled with Technetium-99m Pertectnetate

Chang Shu Tsai; Wei Chung Liu; Hong Yi Chen; Wei Chun Hsu

doi:10.4028/www.scientific.net/AMM.459.51

Paper Titles

Molecular Dynamics Simulation of Stick-Slip Friction on a Metal Surface
p.26

Study on the Effects of Diluent on Silica/Epoxy Resin Composite Material Phase Change
p.34

Optimization of Epoxy Composite on Thermal Decomposition Utilizing Experimental Design Method
p.40

The Structure and Adhesion of Zr/TiAlN Coatings on High-Speed Steel and Cemented Carbide Substrates
p.46

Preparation and Characterization of Fe₃O₄ Magnetic Nanoparticles Labeled with Technetium-99m Pertectnetate
p.51

Predicting the Characteristics of Biofouling Mass Based on Support Vector Machine
p.60

Evaluation of Threshold Condition of Interior Annular Crack Growth in Gigacycle Regime
p.65

Study of Characteristics of Partial Discharge for Assessment of Condition of Electrical Insulating Materials of Power Supply System
p.70

The Study about the Effect of Geometric Parameters' and Material Properties’ Changing on the Electromagnetic Performance of BSSAS
p.76

HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 459Preparation and Characterization of Fe3O4 Magnetic...

Preparation and Characterization of Fe₃O₄ Magnetic Nanoparticles Labeled with Technetium-99m Pertectnetate

Abstract:

In the aspect of biomedical diagnosis, magnetic nanoparticle can be used as drug carrier and MRI/ SPECT/ PET contrast agents. Magnetic fluid hyperthermia is one of the most important cancer therapies. Magnetic nanoparticles display their unique features as heating mediators for hyperthermia. In this study, Fe₃O₄ magnetic nanoparticle was prepared by using chemical co-precipitation method. Tc-99m pertechnetate with Fe₃O₄ magnetic nanoparticles is prepared by using magnet adsorption method. An attempt was also made to evaluate the application in the field of magnetic targeted drug delivery and radioactive targeted cancer treatment in the future. In this work, preparation and characterization of non-polymer and polymer (dextran) coated Fe₃O₄ magnetic nanoparticles labeled with technetium-99m pertectnetate were evaluated and served as precursors study. The Tc-99m labeling efficiency of in-house Fe₃O₄magnetic nanoparticles (MNP) and commercial kit were ca.98.4 % and 85% (n=5), under the same conc. of 6mM, 0.1 ml of SnCl₂·2H₂O, respectively. The Tc-99m labeling efficiency of magnetic nanoparticles with its dextran-coated was ca. 58.2% (n=5) at the same conc. and volume of SnCl₂·2H₂O. The in-vitro stabilities of the 3 kinds of magnetite magnetic fluids were higher than 96.0% (n=5) during 2 hours. The reducing agent of SnCl₂·2H₂O plays a key role due to its reducing ability for Tc-99m pertechnetate. The optimal reaction time of SnCl₂·2H₂O with Tc-99m is better under 1 hour. In conclusion, the Fe₃O₄ magnetic nanoparticle labeled with Tc-99m pertechnetate has shown good qualities for its labeling efficiency and stability. It may be feasible preliminary to utilize in the application of magnetic targeted drug delivery of bio-medicine.