In order to solve two problems when simulating the phenomenon of Shaped Charge Liner penetrating into target, an example was simulated to study the influence of mesh size and target dimension on the penetration results using AUTODYN-2D. The relationship between the Shaped Charge Liner parameters and the critical dimension of the target was gained．The effects of mesh sizes on the penetration depth, aperture，and calculation time were studied. After analyzing the simulation results，a proper range of mesh size was obtained. The simulation results agree well with the test results. The research could provide reference on the simulation of Shaped Charge Liner.