Under dynamic complicated supply chain environment, negotiation efficiency among supply chain members exerts direct influence on the whole performance and competiveness of supply chain. This document combing multi-agent and CBR, puts forward a new supply chain auto-negotiation system model. It analyzes retrieve, reuse, revise and retain of supply chain negotiation case, and establishes supply chain auto-negotiation model based on multi-agent. This system model is helpful for making full use of supply chain historic negotiation experience and experts’ knowledge. It is highly intelligentized which is propitious to promote supply chain negotiation efficiency.