The Approach for Dose-Effect Relationship of TCM Research Based the Overall Effect of Metabonomics

Qi Yun Zhang; Jia Li; Bing Tao Li; Jian Jiang Fu; Ri Yue Yu; Guo Liang Xu

doi:10.4028/www.scientific.net/AMM.590.833

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 590The Approach for Dose-Effect Relationship of TCM...

The Approach for Dose-Effect Relationship of TCM Research Based the Overall Effect of Metabonomics

Abstract:

In this paper, PCA combined with Mass Profiler Professional (MPP) bioinformatics software were used to build the dose-effect relationship of traditional Chinese medicine which based on the overall effect of metabonomics. The dataset from Da Cheng Qi Decoction (DCQD) water extract administrated rats plasma collected by UHPLC-Q-TOF-MS and used to demonstrate this method. The approach was confirmed to be an effective and time-saving tool for describing the dose-effect relationship of traditional Chinese medicine.

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Periodical:

Applied Mechanics and Materials (Volume 590)

Pages:

833-836

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.590.833

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Online since:

June 2014

Authors:

Qi Yun Zhang*, Jia Li, Bing Tao Li, Jian Jiang Fu, Ri Yue Yu, Guo Liang Xu

Keywords:

Dose-Effect Relationship, Metabonomics, Principal Component Analysis (PCA)

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References

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