Non-Newtonian Computational Fluid Dynamics (CFD) Modeling on Left Coronary Artery with Multiple Blockages

Abstract:

The rate of mean blood flow through arteries depend on the resistance to flow presented by the blood vessels. Mean blood pressure decreases as the circulating blood moves away from the heart through arteries and capillaries due to viscous losses of energy. Atherosclerosis is a common phenomenon that is observed causing blockage in coronary arteries leading to cardiac arrest. This blockage is due to the deposition of cholesterol or plaque on the inner walls of the coronary artery. This paper provides an analytical study on the variation of static pressure with multiple blockages in the artery implementing the conventional simulation software. A general three dimensional section of the coronary artery was taken for the analysis and the variation of static pressure with increase in the number of blockages due to cholesterol deposition was studied. Meshing of the geometry and specification of the boundary types have been accomplished using GAMBIT 2.3.16 and the analysis has been carried out using ANSYS FLUENT 6.3.26.

• Periodical: Applied Mechanics and Materials (Volumes 592-594)
• Pages: 1924-1929
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.592-594.1924
• Online since: July 2014
• Authors: Krishna Murari Pandey*, Ritabrata Thakur, Abhinav Hazarika, Tarun Ashutosh, Dipankar Gogoi
• Keywords: Atherosclerosis, CFD, Coronary Artery , Wall Shear Stress

References

[1] Tang D, Yang C, Zheng J, Woodward PK, Saffitz JE, Sicard GA, Pilgram TK, Yuan C, Quantifying Effects of Plaque Structure and Material Properties on Stress Distributions in Human Atherosclerotic Plaques Using 3D FSI Models,. (2005).

DOI: 10.1115/1.2073668

[2] Li Z-Y, Howarth SPS, Tang T and Gillard JH, How Critical Is Fibrous Cap Thickness to Carotid Plaque Stability? A Flow-Plaque Interaction Model,. Stroke 2006, 37: 1195-1199.

DOI: 10.1161/01.str.0000217331.61083.3b

[3] Caro C.G., Discovery of the Role of wall shear in atherosclerosis,. (2009).

[4] Mette S. Olufsen, Charles S. Peskin, Won Yong Kim and Erik M. Pedersen, Ali Nadim and Jesper Larsen, Numerical Simulation and Experimental Validation of Blood Flow in Arteries with Structured-Tree Outflow Conditions,. (2010).

DOI: 10.1114/1.1326031

[5] S. M. Abdul Khader, Anurag Ayachit, B. Raghuvir Pai,V. R. K. Rao, and S. Ganesh Kamath, FSI Simulation of Common Carotid under Normal and High Blood Pressures,. (2012).

DOI: 10.1155/2012/140579

[6] Barbara M. Johnston, Peter R. Johnston, Stuart Corney, David Kilpatrick, Non-Newtonian blood flow in human right coronary arteries: Transient simulations,. Journal of Biomechanics 39 (2006) 1116–1128.

DOI: 10.1016/j.jbiomech.2005.01.034