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Characterizing and Modeling Mechanical Properties of Circulating Tumor Cells by One-Way Fluid Structure Interaction Simulation

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Abstract:

The objective is to study on inverse analysis for the mechanical properties of circulating tumor cells and estimate the mechanical properties. For the adsorbed cells in the micro flow path, experimental image of cell deformation under flow was obtained. The strain is defined based on the image and it is shown for the relationship with flow rate. The fluid analysis was performed to compute the stress acting on the spheres in the micro flow path. The amount of deformation of the cells was examined with changes in the Young's modulus. It consists combining experimental results with a numerical finite element model in order to find out the mechanical properties of circulating tumor cells. The procedure proposed may be also applicable in estimating other physical and mechanical properties of cells.

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Periodical:

Applied Mechanics and Materials (Volume 598)

Pages:

250-253

DOI:

https://doi.org/10.4028/www.scientific.net/AMM.598.250

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Online since:

July 2014

Authors:

Feng Gao*, Gang Li, Takanori Nagasaka, Masanori Hayase, Hiroshi Okada

Keywords:

Circulating Tumor Cells, Finite Element Method (FEM), Mechanical Property, Modeling

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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