Interaction of Particles with the Pulmonary Interface: Effects on Surface Elasticity

Abstract:

We present an experimental study of the interactions of negative and positive model particles and their influence on the surface elasticity of biomimetic pulmonary surfactant. In this purpose we have measured the adhesion force between negative (G) and positive (GS) particles and supported lipid bilayer by Atomic Force Spectroscopy. In addition, the modification in surface elasticity of lipid monolayer under quasistatic compression when interacting with negative and positive particles was investigated on a Langmuir trough. We found that, positive particles interact poorly with biomimetic pulmonary surfactant, therefore no modifications in surface elasticity were observed. Conversely, negative charged particles interact strongly with the biomimetic pulmonary surfactant, decreasing the surface elasticity. The results are directly relevant for understanding the interactions and the effects of particulate matter on pulmonary structures which could lead to pulmonary surfactant inhibition or deficiency causing severe respiratory distress or pathologies.

• Periodical: Applied Mechanics and Materials (Volume 658)
• Pages: 459-464
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.658.459
• Online since: October 2014
• Authors: Bogdan Munteanu*, Yves Berthier, Jean Paul Rieu, Ana Maria Trunfio-Sfarghiu
• Keywords: Adhesion Force, Pollution Particles, Pulmonary Surfactant, Surface Elasticity

References

[1] Brauer, M., Hoek , G., Van Vliet, P., Meliefste, K., Fischer, P. H., Wijga, A., et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. American Journal of Respiratory and Critical Care Medicine , 166: 8, (2002).

DOI: 10.1164/rccm.200108-007oc

[2] Lebeau, B. (1989). Pneumologie (Bd. 1). (Ellipses, Hrsg) Paris.

[3] Kanishtha, T., Banerjee, R., &Venkataraman, C. Effect of particle emissions from biofuel combustion on surface activity of model and therapeutic pulmonary surfactants. Environmental Toxicology and Pharmacology , 22, (2006) 325-333.

DOI: 10.1016/j.etap.2006.05.003

[4] Dockery, D., Pope, C. A., Xu, X., Spengler, J., Ware, J., Fay, M., et al. An association between air pollution and mortality in six U.S. cities. New England Journal of Medicine , 329, 1753-1759.

DOI: 10.1056/nejm199312093292401

[5] Zanobetti, A., Schwartz, J., & Dockery, D. W. Airborne particles are a risk factor for hospital admissions for heart and lung disease. Environmental health perspectives , 108: 11, (2000) 1071-1077.

DOI: 10.1289/ehp.001081071

[6] Boldo, E., Medina, S., Le Tertre, A., Hurley, F., Mucke, H. G., Ballester, F., et al. Apheis: Health Impact Assessment of Long-term Exposure to PM2. 5 in 23 European Cities. European Journal of Epidemiology , 21: 6, (2006) 449-458.

DOI: 10.1007/s10654-006-9014-0

[7] Watkiss, P., Pye, S., & Holland, M. Service Contract for carrying out cost-benefit analysis of air quality related issues, in particular in the clean air for Europe (CAFE) programme. European Commission DG Environment (2003).

[8] Hills, B. A. The role of lung surfactant. BJA British Journal of Anaesthesia , 65: 1, (1990) 13-29.

[9] Harb, F., Simon, A., &Tinland, B. (2013). Ripple formation in unilamellar-supported lipid bilayer revealed by FRAPP. The European physical journal. E, Soft matter , 36: 12, (1993) 1-7.

DOI: 10.1140/epje/i2013-13140-x

[10] Behroozi, F. Theory of Elasticity in Two Dimensions and Its Application to Langmuir−Blodgett Films. Langmuir, 12: 9, (1996) 2289–2291.

DOI: 10.1021/la950636h

[11] Munteanu B., Berthier Y., Rieu J-P., Trunfio-Sfarghiu A-M., Effect of ions on the interactions of glass nanoparticles with monolayer lung surfactant: Applications for the study of inhaled airborne wear particles, Computer Methods in Biomechanics and Biomedical Engineering, 16, (2013).

DOI: 10.1080/10255842.2013.815877