Preparation of Compound Aloe Film and Tests of its Film Performance

Abstract:

OBJECTIVE To prepare traditional Chinese pharmaceutical film which can be absorbed through derma and have an effect of topical antibacterial , and take examinations of its film performance. METHODS The active ingredients extracted from the traditional Chinese medicine such as Aloe are blended in a certain proportion as the dressing of chitosan and casted into films. The thickness of the films were measured by the thickness measurement instrument, and the performance of the films was tested and compared such as film forming, swelling and solubility, water holding capacity and permeability. RESULTS Aloe compound film as external applied agent has a desired film performance. CONCLUSION Aloe compound film which could be transdermally absorbed presents a promising potential in adjuvant therapy of ulcers, bedsores and other skin of mucous membrane infections.

• Periodical: Applied Mechanics and Materials (Volumes 66-68)
• Pages: 2028-2033
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.66-68.2028
• Online since: July 2011
• Authors: Chun Lan Xue, Wei Gao, Ying Li, Jing Zhi Tong, Shuo Zhang, Yan Wen Zhang
• Keywords: Compound Aloe Film, Film Performance, Mucous Membrane Infection, Skin Infection

References

[1] Pharmacopoeia of the Peoples Republic of China, 2005, vol 1: 112-113.

[2] KAR A, PANDA S, BHARTI S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice [J]. J. Ethnopharmacol, 2002, 81: 281-285.

DOI: 10.1016/s0378-8741(02)00048-x

[3] LI ZH F, SHAO W, DING J, et al. Experimental study on bacteriostatic efficacy and toxicity of aloe extract [J]. Chinese Journal of Disinfection, 2008, 25(4): 384-385.

[4] SYDISKIS R J, OWEN D G, LOHR J L, et al. Inactivation of enveloped viruses by anthraquinones extracted from plants [J]. Antimicrob Agents Chemother, 1991, 35(12): 2463-2466.

DOI: 10.1128/aac.35.12.2463

[5] PI W X, DING H, CHENG AI B, et a1. Purification process of Aloe polysaccharide and its anti-tumor activity in vitro [J]. Chin J nat Med, 2007, 5(6): 425-427.

[6] CHOI S W, SON B W, Son Y S, et a1. The wound-healing effect of a glycoprotein fraction isolated from aloe vera [J]. Br J Dermatol，2001, 145(4): 535-545.

DOI: 10.1046/j.1365-2133.2001.04410.x

[7] JIANG W. Medical Chemistry Experiment [M]. Beijing: Higher Education Press, 2006. 79-81.

[8] LIU Q B, ZHAO J S. Study on aloe gelatin edible films [J]. Science and Technology of Food Industry, 2006, 27(7) : 80-82.

[9] ZHANG W M, MA SH H, GU G P, et al. Studies on the toxicological assessment on skin safety of polysaccharide gum of common bletilla tuber (thunb. ) reichb. f. [J]. Chinese Wild Plant Resources, 2003, 22(5): 59-61.

[10] YU Q, CAI K, TIAN W Y. Ethanol extract of white japonica preliminary study on the immune activity [J]. Journal of Guiyang College of Traditional Chinese Medicine, 2005, 27(2): 20-21.

[11] JIN M X, HU Q H. The nature of chitosan and its application in bio-adhesive drug delivery systems [J]. Central South Pharmacy, 2008, 6(3): 324-327.