Efficient Synthesis of DiAZT Triphosphate

Shan Shan Gong; Qi Sun

doi:10.4028/www.scientific.net/AMM.662.59

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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vol. 662Efficient Synthesis of DiAZT Triphosphate

Efficient Synthesis of DiAZT Triphosphate

Abstract:

A facile and efficient method for the synthesis of P¹,P³-dizidovudine-5′,5′-triphosphate has been developed. The coupling of zidovudine diphosphate with zidovudine phosphoropiperidate based on the DCI activation of P-N bond afforded the desired product in good yield.

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Applied Mechanics and Materials (Volume 662)

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59-62

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https://doi.org/10.4028/www.scientific.net/AMM.662.59

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Online since:

October 2014

Authors:

Shan Shan Gong, Qi Sun*

Keywords:

Antiviral Nucleoside, Dicyanoimidazole, Dinucleoside Triphosphate, Zidovudine

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* - Corresponding Author

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