Efficient Synthesis of Functionalized 3-Aminopropanols

Abstract:

A series of α-aminophosphonate-functionalized 3-aminopropanols have been efficiently prepared and characterized by ¹H, ¹³C, and ³¹P NMR and mass spectroscopy. The reaction conditions such as solvent and temperature were thoroughly investigated based on the three-component Kabachnik-Fields reaction. The experimental results revealed that moderate elevation of reaction temperature under solvent-free conditions was optimal for the synthesis of these types of compounds without forming the cyclized byproduct.

• Periodical: Applied Mechanics and Materials (Volume 662)
• Pages: 67-70
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.662.67
• Online since: October 2014
• Authors: Xiao Chuan Li, Shan Shan Gong, Qi Sun*
• Keywords: 3-Aminopropanol, Aminophosphonate, Kabachnik-Fields Reaction, Solvent-Free

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