Anti-Anxiety Effect of Schisandra chinensis Baill Lignans on Mice in Elevated Plus Maze Test

Abstract:

Elevated plus maze was used to establish an animal anxiety model to investigate the anti-anxiety effect of Schisandra Chinensis (Turcz.) Baill lignans (SCL). OE, OT, CE and CT were observed, and based on them, the ratio of OE (OE%) and the ratio of OT (OT%) were calculated, respectively. It was considered that the fewer the OE was and the shorter the OT was, the more serious the anxiety of mice was. The results showed that compared with those in the control group, both OE% and OT% presented an increasing trend in the different dose SCL groups, indicating that SCL has an anti-anxiety effect; there were significant differences in the anti-anxiety effect between 70 mg/kg SCL and 140 mg/kg SCL groups, and the control group, but no difference in it between 35 mg/kg SCL group and the control group, indicating that the anti-anxiety effect of SCL may be dose-related.

• Periodical: Applied Mechanics and Materials (Volumes 675-677)
• Pages: 1580-1583
• DOI: https://doi.org/10.4028/www.scientific.net/AMM.675-677.1580
• Online since: October 2014
• Authors: Tao Jiang, Xin Tian Fan, Chun Mei Wang, Li Mei Chen, Jing Hui Sun, Wei Jing Sun, Jian Guang Chen, He Li*
• Keywords: Anxiety Disorders, Elevated Plus Maze, Schisandra chinensis (Turcz.) Baill Lignans

References

[1] H. Lowther, E. Newman, Attention bias modification (ABM) as a treatment for child and adolescent anxiety: A systematic review. J Affect Disord. 168C (2014) 125-135.

DOI: 10.1016/j.jad.2014.06.051

[2] E.J. Bluett, K.J. Homan, K.L. Morrison, M.E. Levin, M.P. Twohig, Acceptance and commitment therapy for anxiety and OCD spectrum disorders: An empirical review. J Anxiety Disord. Forum Vol. 28 (2014) 612-624.

DOI: 10.1016/j.janxdis.2014.06.008

[3] F.D. Alosaimi, O. Al-Sultan, Q. Alghamdi, I. Almohaimeed, S, Association of help-seeking behavior with depression and anxiety disorders among gastroenterological patients in Saudi Arabia. Alqannas. Saudi J Gastroenterol. Forum Vol. 20 (2014).

DOI: 10.4103/1319-3767.136977

[4] A.M. Norr, N.P. Allan, R.J. Macatee, M.E. Keough, N. B, The effects of an anxiety sensitivity intervention on anxiety, depression, and worry: Mediation through affect tolerances. Schmidt. Behav Res Ther. 59 (2014) 12-19.

DOI: 10.1016/j.brat.2014.05.011

[5] H. Teng, W.Y. Lee, Antibacterial and antioxidant activities and chemical compositions of volatile oils extracted from Schisandra chinensis Baill. seeds using simultaneous distillation extraction method, and comparison with Soxhlet and microwave-assisted extraction. Biosci Biotechnol Biochem. 78 (2014).

DOI: 10.1080/09168451.2014.877815

[6] Z. Yao, X.C. Liu, Y.E. Gu, Schisandra chinensis Baill, a Chinese medicinal herb, alleviates high-fat-diet-inducing non-alcoholic steatohepatitis in rats. Afr J Tradit Complement Altern Med. 11 (2013) 222-227.

DOI: 10.4314/ajtcam.v11i1.35

[7] J.H. Lee, J.Y. Kim, J. W, Highly Palatable Food during Adolescence Improves Anxiety-Like Behaviors and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Rats that Experienced Neonatal Maternal Separation. Jahng. Endocrinol Metab (Seoul). 29 (2014).

DOI: 10.3803/enm.2014.29.2.169