The Biocompatibility of Ti Alloy Improved by Nitrogen-Doped Diamond-Like Carbon Films

Article Preview

Abstract:

The nitrogen-doped diamond-like carbon film was prepared on Ti6Al4V alloy by using plasma enhanced chemical vapor deposition (PECVD) technique,and its biocompatibility was studied.The surface morphology,chemical composition and contact angle were measured by scanning electron microscope (SEM),X-ray photoelectron spectroscopy(XPS),Raman Spectrometer and contact angle measuring device. Finally, the proliferation rate and cellular morphology of 3T3-E1 osteoblast cells on different sample surfaces were tested and Image J software was used to statistically analyze the count of the adhered cells. The results showed that cell adhesion and proliferation were significantly (P<0.05) increased on nitrogen-doped diamond-like carbon films , which illustrated that N doping improved the biocompatibility of DLC films. This finding has potential clinical application value to modify titanium alloy for new bone formation.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

250-254

Citation:

Online since:

December 2014

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2015 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] Ma WJ, Ruys AJ, Mason RS, Martin PJ, Bendavid A, Liu Z, Ionescu M, Zreiqat H. DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials 2007; 28: 1620–1628.

DOI: 10.1016/j.biomaterials.2006.12.010

Google Scholar

[2] Roy RK, Lee KR. Biomedical applications of diamond-like carbon coatings: A review. J. Biomed Mater Res B: Appl Biomater 2007; 83: 72–84.

Google Scholar

[3] Cui FZ, Li DJ. A review of investigations on biocompatibility of diamond-like carbon and carbon nitride films. Surf Coat Technol2000; 131: 481–487.

DOI: 10.1016/s0257-8972(00)00809-4

Google Scholar

[4] Grill A. Diamond-like carbon coatings as biocompatible materials: An overview. Diamond Relat Mater 2003; 12: 166–170.

DOI: 10.1016/s0925-9635(03)00018-9

Google Scholar

[5] Ji L, Li H, Zhao F, Chen J, Zhou H. Microstructure and mechanical properties of Mo/DLC nanocomposite films. Diamond Relat Mater2008; 17: 1949–(1954).

DOI: 10.1016/j.diamond.2008.04.018

Google Scholar

[6] Khun NW, Liu E, Yang GC. Structure, scratch resistance and corrosion performance of nickel doped diamond-like carbon thin films. Surf Coat Technol 2010; 204: 3125–3130.

DOI: 10.1016/j.surfcoat.2010.02.057

Google Scholar

[7] Dai W, Wang A. Deposition and properties of Al-containing diamond-like carbon films by a hybrid ion beam sources. J Alloys Compd 2011; 509: 4626–4631.

DOI: 10.1016/j.jallcom.2011.01.132

Google Scholar

[8] Gutensohn K, Beythien C, Bau J, Fenner T, Grewe P, Koester R, Padmanaban K, Kuehnl P. In vitro analyses of diamond-like carbon coated stents: Reduction of metal ion release, platelet activation, and thrombogenicity. Thromb Res 2000; 99: 577–585.

DOI: 10.1016/s0049-3848(00)00295-4

Google Scholar

[9] Gillespie WJ, Frampton CMA, Henderson RJ, Ryan PM. The incidence of cancer following total hip replacement. J Bone Joint Surg Br 1988; 70: 539–542.

DOI: 10.1302/0301-620x.70b4.3403594

Google Scholar

[10] Liao W H, Lin C R, Wei D H, et al. Concurrent improvement in biocompatibility and bioinertness of diamond‐like carbon films with nitrogen doping[J]. Journal of Biomedical Materials Research Part A, 2012, 100(11): 3151-3156.

DOI: 10.1002/jbm.a.34235

Google Scholar

[11] Sen A, Barizuddin S, Hossain M, Polo-Parada L, Gillis KD, Gangopadhyay S. Preferential cell attachment to nitrogen-doped diamond-like carbon (DLC: N) for the measurement of quantal exocytosis. Biomaterials 2009; 30: 1604–1612.

DOI: 10.1016/j.biomaterials.2008.11.039

Google Scholar

[12] Xu LC, Siedlecki CA. Effects of surface wettability and contact time on protein adhesion to biomaterial surfaces. Biomaterials2007; 22: 3273–3283.

DOI: 10.1016/j.biomaterials.2007.03.032

Google Scholar