Bio-Functionalization of Carbon Nanotubes and Intracellular Imaging

Jun Li; Yao Dong Dai

doi:10.4028/www.scientific.net/AMM.799-800.471

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Bio-Functionalization of Carbon Nanotubes and Intracellular Imaging
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HomeApplied Mechanics and MaterialsApplied Mechanics and Materials Vols. 799-800Bio-Functionalization of Carbon Nanotubes and...

Bio-Functionalization of Carbon Nanotubes and Intracellular Imaging

Abstract:

Shortened single walled carbon nanotubes (SWNTs) were functionalized with chitosan (CS) oligomer to improve their water solubility and biocompatibility. The functional groups such as amino in CS benefit the further modification of other bio-functional molecules. Fluorescein isothiocyanate (FITC) were marked in CS decorated SWNTs through covalent bond for imaging and tracking SWNTs. Water soluble SWNTs wrapped by CS could also be suitable for drug delivery. Tea polyphenol (TP) and doxorubicin (DOX) drug molecules were loaded in the SWNTs system respectively through hydrogen bond and π-π interaction. The FITC labeled CS/SWNTs were co-incubated with cells and imaged under laser scanning confocal microscope (LSCM). With proper bio-functionalization, SWNTs could be easily internalized by cells via endocytosis.

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Periodical:

Applied Mechanics and Materials (Volumes 799-800)

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471-474

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https://doi.org/10.4028/www.scientific.net/AMM.799-800.471

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Online since:

October 2015

Authors:

Jun Li, Yao Dong Dai*

Keywords:

Bio-Functionalization, Carbon Nanotubes, Chitosan

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* - Corresponding Author

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