Synthesis of Poly(D,L-Lactic Acid-Co-Glucose) via Direct Polycondensation and its Characterization

Abstract:

Article Preview

Directly using cheap D,L-lactic acid (D,L-LA) and glucose (Glu) as starting materials, biodegradable material poly(D,L-lactic acid-co-Glucose) [P(D,L-LA-co-Glu)] was synthesized via melt polycondensation. When n(Glu) : n(D,L-LA) = 1:200, the appropriate synthetic condition is that: after 120 °C prepolymerization for 5 h, 160 °C melt polymerization catalyzed by w(SnCl2) = 0.5% for 5 h. P(D,L-LA-co-Glu) with different molar feed ratios were synthesized and characterized with [η], FTIR, 1H NMR, GPC and XRD. The Tg of all copolymer P(D,L-LA-co-Glu) was lower than that of homopolymer polylactic acid directly synthesized via melt polycondensation. The copolymers with Mw from 2,100 Da to 5,100 Da could meet the demand of drug delivery carrier material.

Info:

Periodical:

Edited by:

Linli Xu, Wenya Tian and Elwin Mao

Pages:

370-374

DOI:

10.4028/www.scientific.net/AMM.80-81.370

Citation:

S. H. Luo et al., "Synthesis of Poly(D,L-Lactic Acid-Co-Glucose) via Direct Polycondensation and its Characterization", Applied Mechanics and Materials, Vols. 80-81, pp. 370-374, 2011

Online since:

July 2011

Export:

Price:

$35.00

In order to see related information, you need to Login.

In order to see related information, you need to Login.