In this article, an inclined leg bridge is taken as the research object. The three-dimensional finite element model is established, and soil spring is used to simulate soil-pile interaction. The dynamic characteristics of the two models are calculated. Two different ground motions are selected to analyze seismic response of the bridge. The dynamic characteristics and seismic response of bridge are compared in the conditions whether considering soil-pile interaction. The results show that the stress and displacement under qian’an ground motion action is bigger than that under Elcentro ground motion because the two ground motions have different frequency characteristics .After considering soil-pile interaction, the natural frequencies of inclined leg bridge decrease, and the longitudinal displacement of bridge increases obviously, at the same time the stress in the top and bottom of inclined leg increase obviously and the stress among main girder is not obviously increased. Soil-pile interaction maybe cause some adverse effect for inclined leg rigid frame bridge.