The response surface method (RSM) developed in recent years is an effective way to solve the structural reliability problems with implicit performance function. In order to improve the computational efficiency and make RSM suitable well to large and complex engineering structures, the reliability analysis method based on uniform design method (UDM) and support vector machine (SVM) was proposed. UDM is adopted to select training data and SVM is used as response surface. Structural reliability index is calculated in combination with the traditional reliability analysis methods (such as, the first-order reliability method (FORM), the second-order reliability method (SORM) or Monte Carlo simulation method (MCSM)). Numerical examples show that sampled with the UDM can greatly reduce the number of samples required for training by SVM model, and a very good approximation of the limit state surface can be obtained to get the failure probability. The reliability analysis of the under serviceability limit-state of a typical self-anchored suspension bridge——Sanchaji Bridge was carried out with the improved response surface method.