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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1023Synthesis of Symmetrical Dipurine-Nucleoside...

Synthesis of Symmetrical Dipurine-Nucleoside Diphosphates from the Corresponding Nucleoside Phosphoropiperidates

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Abstract:

A general and efficient method for the preparation of symmetrical dinucleoside diphosphates with purine bases has been developed. Ap₂A and Gp₂G were synthesized from the in situ hydrolysis of corresponding nucleoside 5′-phosphoropiperidates with 4,5-dicyanoimidazole as the activator. This method features easily accessible starting materials, simple procedures, and good yield.

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Advanced Research on Energy, Chemistry, Materials and Informatization III

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Periodical:

Advanced Materials Research (Volume 1023)

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55-58

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1023.55

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Online since:

August 2014

Authors:

Xiao Chuan Li, Shan Shan Gong, Qi Sun*

Keywords:

4,5-Dicyanoimidazole, Dinucleoside Diphosphate, Phosphoropiperidate, Purine

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© 2014 Trans Tech Publications Ltd. All Rights Reserved

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