Hydrolyzed Fish Collagen Inhibits Inflammatory Cytokines Secretion in Lipopolysaccharide-Induced HUVECs

Chao Liu; Yang Xue; Jiao Sun

doi:10.4028/www.scientific.net/AMR.1025-1026.570

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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 1025-1026Hydrolyzed Fish Collagen Inhibits Inflammatory...

Hydrolyzed Fish Collagen Inhibits Inflammatory Cytokines Secretion in Lipopolysaccharide-Induced HUVECs

Abstract:

The present study was designed to investigate the effects of hydrolyzed fish collagen (HFC) on the cytokine production of lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs). The in vitro inflammation model was established using LPS-induced HUVECs.The cell viability of HUVECs and the secretion level of inflammatory cytokines,IL-6, IL-8, and TNF-α from LPS-treated HUVECs exposed to HFC were determined respectively using MTT and ELISA assays. Our results indicate that HFC promoted HUVECs proliferation, and significantly reduced IL-6, IL-8, and TNF-α production in LPS-stimulated HUVECs. It suggested that HFC had a prominent anti-inflammatory property, HFC could be considered as a promising candidate for anti-inflammatory wound dressing.

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Periodical:

Advanced Materials Research (Volumes 1025-1026)

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570-573

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1025-1026.570

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Online since:

September 2014

Authors:

Chao Liu, Yang Xue, Jiao Sun*

Keywords:

Anti-Inflammatory, HUVECs, Hydrolyzed Fish Collagen, Inflammatory Cytokines

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* - Corresponding Author

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