Preliminary Toxicology Evaluation of Silymarin

Abstract:

Research silymarin food security through animal experiments. Acute toxicity test, mouse bone marrow micronucleus test, mice sperm abnormality test results were evaluated. Male and female mice by oral maximum tolerated dose (MTD) are more than 20.0g/kg body weight, according to the acute toxicity grading standards, which are non-toxic level. Mouse bone marrow micronucleus test, mice sperm abnormality test and genotoxicity test were negative. Showed that silymarin is a food safety component.

• Periodical: Advanced Materials Research (Volumes 1049-1050)
• Pages: 544-546
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1049-1050.544
• Online since: October 2014
• Authors: Fei Zhao*, Xin Hua Li
• Keywords: Safety Evaluation, Silymarin, Toxicology

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