Effect of Doped Traditional Chinese Medicine Drynariae Rhizoma on the Porcine Bone Hydroxyapatite and Chitosan Porous Scaffold

Abstract:

Chinese medicine Drynariae Rhizoma extract (DR) was introduced into porcine bone hydroxyapatite (PBHA) and chitosan (CS) for the preparation of scaffold by the Vacuum freeze drying method in order to accelerate bone growth and weak bone adhesion in the early healing stage of scaffold. The microscopic morphology and composition of the scaffolds were analyzed by SEM, XRD and IR. Compressive strength of the scaffold and the porosity was tested. Biological activity of the scaffolds was studied by immersed in Simulated Body Fluid (SBF). The scaffolds were a high porosity of 80% and compressive strength of 1.2MPa. Carbonate containing bone-like HA was formed on the surface of the scaffold after immersion in SBF, showing that the scaffold materials have good bone-like apatite forming ability. The scaffolds of DR -PBHA- CS have good physical and chemical properties, good biological activity and low price.

• Periodical: Advanced Materials Research (Volumes 105-106)
• Pages: 561-564
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.105-106.561
• Online since: April 2010
• Authors: Mu Qin Li, Jing Yan Wang, Chen Ma
• Keywords: Chitosan (CS), Drynariae Rhizoma, Porcine Bone Hydroxyapatite, Silane Coupling Agent

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