Borneol-Shellac Nanofiber Membranes Fabricated Using a Modified Coaxial Electrospinning

Deng Guang Yu; Ying Xu; Song Liu; Yu Hai Wang; Xiao Duan; Xia Wang

doi:10.4028/www.scientific.net/AMR.1058.78

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1058Borneol-Shellac Nanofiber Membranes Fabricated...

Borneol-Shellac Nanofiber Membranes Fabricated Using a Modified Coaxial Electrospinning

Abstract:

A modified coaxial electrospinning process is developed for producing medicated nanofiber membranes of shellac. With pure ethanol as a sheath fluid, high quality borneol-loaded shellac nanofibers have been successfully fabricated using the modified coaxial process. Electron scanning microscopic observations demonstrated that the nanofibers had better quality than those fabricated using a single fluid electrospinning in terms of nanofiber diameters and their distributions. The former had an average diameter of 570 ± 80 nm under a sheath-to-core flow rate ratio of 0.25, whereas the later was 940 ± 230 nm. X-ray diffraction results verified that borneol existed in the shellac matrix in an amorphous state. The medicated nanofiber membranes could significantly improved the physical stability of borneol due to the favorable hydrogen bonding between the drug and the polymer matrix, as demonstrated by the weight loss experiments. The modified coaxial electrospinning process described here expands the capability of electrospinning process in generating high quality functional membranes.

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Periodical:

Advanced Materials Research (Volume 1058)

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78-82

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https://doi.org/10.4028/www.scientific.net/AMR.1058.78

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Online since:

November 2014

Authors:

Deng Guang Yu*, Ying Xu, Song Liu, Yu Hai Wang, Xiao Duan, Xia Wang

Keywords:

Borneol, Coaxial Electrospinning, Medicated Anofibers, Shellac, Stability

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