Effect of Lipophilicity of Drugs on Dissolution Profiles of Self-Nanoemulsifying Drug Delivery System

Abstract:

The low solubility of poorly water-soluble drug is a major problem of oral drug adsorption. The self-emulsifying system can be applied to eliminate the drug dissolution step and improve the drug absorption. In this research, liquid self-nanoemulsifying drug delivery system (SNEDDS) composing of polyethoxylated castor oil, caprylic/capric glyceride and diethylene glycol monoethyl ether was developed. The drugs with similar structure but different lipophilicity (log P), nifedipine (NDP), felodipine (FDP) and manidipine (MDP), were investigated. Size and size distribution of emulsion after dilution in acid medium and in vitro drug dissolution were determined. The results showed that the size of emulsions obtained from dilution of SNEDDS in acidic medium ranged from 100-150 nm. Drug dissolution from SNEDDS was different depending on lipophilicity of drug, i.e., 98.6, 74.3 and 52.5% for NDP (log P 2.50), FDP (log P 4.46) and MDP (log P 5.46), respectively. The results suggested that the difference in lipophilicity may influence the drug dissolution from SNEDDS.

• Periodical: Advanced Materials Research (Volume 1060)
• Pages: 37-40
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1060.37
• Online since: December 2014
• Authors: Yotsanan Weerapol, Sontaya Limmatvapirat, Pornsak Sriamornsak*
• Keywords: Lipophilicity, Log P, Poorly Water-Soluble Drug, Self-Nanoemulsifying Drug Delivery System, SNEDDS

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