Preparation of Centella Extracts Loaded Aloe Vera Transdermal Patches for Wound Healing Purpose

Abstract:

Transdermal patch is a drug delivery system using a polymer for controlling the drug release. In this study, polysaccharides from aloe vera gel were used as polymer in transdermal patches because they are compatible, biodegradable, and safe to apply on skin without any side effect. Pentacyclic triterpenoids rich (asiatic acid, madecassic acid, asiaticoside and madecassoside) Centella asiatica extracts were added as active ingredients. Both polymer and active ingredients show pharmacological effects as wound healing. It was found that the optimized formulation contained polysaccharides from aloe vera gel blended with 20% glycerine and 15% sodium alginate calculated based on aloe vera mass could produce the good films. These films could be controlled with respect to physical properties thickness (0.509±0.015 mm), tensile strength (1.391±0.131 MPa), elongation at break (116.2±13.15%), peel strength (0.116±0.044 N), the highest swelling times (20 minutes), and the percentage of degradation at 30 minutes (51.57±5.96%). About 0.34 % centella extracts (57% pentacyclic triterpenoids) could be found in these films. After stability studies at 4, 25 and 45 °C for 10 weeks, films stored at 45 °C were loss of flexibility and brittleness that could not be further evaluated. While films stored at 4 and 25 °C were good physiochemical properties and stable as same as films base.

• Periodical: Advanced Materials Research (Volume 1060)
• Pages: 54-57
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1060.54
• Online since: December 2014
• Authors: Panupong Puttarak*, Wiwat Pichayakorn, Kanchana Sripoka, Khwanrudee Chaimud, Pharkphoom Panichayupakaranant
• Keywords: Aloe Vera Gel, Centella Extract, Polysaccharides, Transdermal Patch

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