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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1060Decylglucoside Microemulsion Systems Containing...

Decylglucoside Microemulsion Systems Containing Coenzyme Q10: Formulation, Physicochemical Characterization and Stability

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Abstract:

This study aimed to develop green microemulsions (MEs) for loading coenzyme Q10 (CoQ10). Decylglucoside, a surfactant in the group of alkyl polyglycosides (APG), was used in the formulations since it is biodegradable and non-ionic, leading to low toxic products and friendly properties to the environment. Two blank MEs, i.e., M1 and M2 were prepared by simple mixing dicaprylyl ether, decylglucoside, sorbotan monolaurate and water in the concentrations of 70%, 2.5%, 22.5% and 5%, respectively for M1 and 60%, 6%, 24% and 10%, respectively for M2. Afterwards, M1 and M2 were incorporated with 5% CoQ10 to obtained QM1 and QM2, respectively. All samples were studied for physicochemical properties and stability under accelerated condition. It was found that they were transparence and absence of liquid crystals. Their rheological profiles indicated low viscosity and Newtonian flow. After stability test by freeze thaw for 5 cycles, physicochemical properties of M1, M2, QM1 and QM2 were not obviously different from those at the initial. In addition, more than 97% of label amount of CoQ10 were found in both QM1 and QM2 after stability study. The results indicated that the investigated decylglucoside MEs were suitable systems for incorporation with CoQ10.

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Periodical:

Advanced Materials Research (Volume 1060)

Pages:

70-73

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.1060.70

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Online since:

December 2014

Authors:

Natthida Pakpayat*, Prapaporn Boonme

Keywords:

Coenzyme Q10, Decylglucoside, Microemulsion, Stability

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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[1] L. Ernster, G. Dallner, Biochemical, physiological and medical aspects of ubiquinone function, Biochem. Biophys. Acta. 1271 (1995) 195-204.

DOI: 10.1016/0925-4439(95)00028-3

[2] G. Lenez, R. Fato, G. Formiggini, M.L. Genova, The role of coenzyme Q in mitocondrial electron transport, Mitochondrion 7 (2007) S8-S33.

DOI: 10.1016/j.mito.2007.03.009

[3] R.E. Beyer, The participation of coenzyme Q in free radical production and antioxidation, Free Radic. Biol. Med. 8 (1990) 545–565.

DOI: 10.1016/0891-5849(90)90154-b

[4] S. Pepe, S. Marasco, S. Haas, F. Sheeran, H. Krum, F. Rosenfeldt, Coenzyme Q10 in cardiovascular disease, Mitochondrion, 7 (2007) S154–S167.

DOI: 10.1016/j.mito.2007.02.005

[5] T.D. Rozen, M.L. Oshinsky, C.A. Gebeline, K.C. Bradley, W.B. Young, A.L. Shechter, S.D. Silberstein, Open label trial of coenzyme Q10 as a migraine preventive, Cephalalgia 22 (2002) 137–141.

DOI: 10.1046/j.1468-2982.2002.00335.x

[6] C.W. Shults, Coenzyme Q10 in neurodegenerative diseases, Curr. Med. Chem. 10 (2003) 1917–(1921).

DOI: 10.2174/0929867033456882

[7] K. Sakano, M. Takahashi, M. Kitano, T. Sugimura, K. Wakabayashi, Suppression of azoxymethane-induced colonic premalignant lesion formation by coenzyme Q10 in rats, Asian Pac. J. Cancer Prev. 7 (2006) 599–603.

[8] A. Kogan, N. Garti, Microemulsion as transdermal drug delivery vehicles, Adv. Colloid Interface Sci. 123 (2006) 369-385.

DOI: 10.1016/j.cis.2006.05.014

[9] M. Kreilgaard, Influence of microemulsions on cutaneoud drug delivery, Adv Drug Deliv Rev. 54 (2002) S77-98.

DOI: 10.1016/s0169-409x(02)00116-3

[10] A. Ceglie, K.P. Das, B. Lindman, Microemulsion structure in four-component systems for different surfactants, Colloids Surf. 28 (1987) 29-40.

DOI: 10.1016/0166-6622(87)80164-6

[11] I. Danielsson, B. Lindmann, The definition of a microemulsion, Colloid Surf. 3 (1981) 391-392.

[12] K. Holmberg, Natural surfactants, Curr. Opin. Colloid Interface Sci. 6 (2001) 148-159.

[13] N. Pakpayat, S. Yotsawimonwat, P. Boonme, Green microemulsions for cosmetics, Thai Pharm. Health Sci. 6 (2011) 290-298. (in Thai).

[14] N. Pakpayat, F. Nielloud, R. Fortune, C.T. Peteilh, A. Villarreal, I. Grillo, B. Bataille, Formulation of ascorbic acid microemulsions with alkyl polyglycosides, Eur. J. Pharm Biopharm. 72 (2009) 444-452.

DOI: 10.1016/j.ejpb.2009.01.005

[15] C. Schulreicha, C. Angermannb, S. Höhnb, R. Neubauerb, S. Seibtb, R. Stehlec, A. Lappd, A. Richardte, A. Diekmannf, T. Hellwega, Bicontinuous microemulsions with extremely high temperature stability based on skin friendly oil and sugar surfactant, Colloids Surf. A: Physicochem. Eng. Aspects 418 (2013).

DOI: 10.1016/j.colsurfa.2012.10.039