Applications of Chemical Factors in Steroid Bioconversion

Abstract:

Microbial conversion is a key process in the biosynthetic routes of steroid medicine.The whole process of bioconversion includes two essential steps: (1) enzymatic reaction step where the enzyme-catalyzed substrate transformation takes place inside the cells, and (2) diffusion step that includes the diffusion of substrate molecules from the surface of solid substrate particles into bulk media (i.e., the solubilization of solid substrate), the diffusion of solubilized substrate molecules from bulk media into cells, and the diffusion of formed product molecules from inside cells into bulk media. In this review, the applications of three chemical factors (growth regulator,surfactant and cyclodextrin), and their effects on steroid microbial enzymatic conversion were extensively discussed, which provides insights into the development of novel approaches to cost-effectively improve biosynthesis efficiency in steroid medicine.

• Periodical: Advanced Materials Research (Volumes 1073-1076)
• Pages: 159-164
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1073-1076.159
• Online since: December 2014
• Authors: Xiao Jing Li*, Xiao Jie Wang, Yun Zhe Ji
• Keywords: Cyclodextrin, Growth Regulator, Microbial Enzymatic Reaction, Steroid Bioconversion, Surfactant

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