Fabrication an Antibacterial Surface on Composite Porous Scaffold

Abstract:

Elimination of the residual microorganisms from an infectious bone defects and the prevention of subsequent re-infection are of importance for chronic osteomyelitis treatment. The application of bone repair materials with antibacterial properties in such a condition has advantages. The present study reported a novel method to fabricate nanohydroxyapatite/polyurethane (n-HA/PU) based antibacterial porous scaffolds through immobilization "core-shell" silver-based mesoporous silica particles (Ag@SiO₂), i.e., silver nanoparticle as core and mesoporous silica as shell, on the surface of n-HA/PU scaffold. The samples were characterized by Scanning Electron Microscope (SEM) and antibacterial tests. The results revealed that the Ag@SiO₂ nanoparticles distributed uniformly on the surface of n-HA/PU porous scaffold. The Ag@SiO₂ could been kept on the surface of n-HA/PU porous scaffold more than 2 weeks, resulting in long-lasting the release of silver ions and antibacterial ability. The porous n-HA/PU scaffolds with an antibacterial surface may hold promise to be used in infectious bone defects repair.

• Periodical: Advanced Materials Research (Volume 1095)
• Pages: 291-294
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1095.291
• Online since: March 2015
• Authors: Jia Xing Jiang, Li Mei Li, Jian Wang, Gen Li, Yi Zuo, Yu Bao Li, Ji Dong Li*
• Keywords: Antibacterial, Mesoporous Silica, Nanohydroxyapatite, Polyurethane, Silver

References

[1] A.G. Gristina, Science. Vol. 237 (1987), p.1588.

[2] P. Stoodley, S. Kathju, F.Z. Hu, G. Erdos, J.E. Levenson, N. Mehta, B. Dice, S. Johnson, L. Hall-Stoodley and L. Nistico, Clin Orthop Relat Res. Vol. 437(2005), p.31.

DOI: 10.1097/01.blo.0000175129.83084.d5

[3] Y. TABATA, Necessity of drug delivery systems to tissue engineering, in Biomaterials and Drug Delivery Toward the New Millennium, edited by K. D. Park (Han Rim Won Publisher, Seoul, Korea, 2000).

[4] D. Huang, Y. Zuo, Q. Zou, L. Zhang, J.D. Li, L. Cheng, J. Shen and Y.B. Li, J. Biomater. Sci. Polym. Ed. Vol. 22(2011), p.931.

[5] J.E. Gray, P.R. Norton, R. Alnouno, C.L. Marolda, M.A. Valvano and K. Griffiths, Biomaterials. Vol. 24(2003), p.2759.

DOI: 10.1016/s0142-9612(03)00057-7

[6] H. Yang, Y. Liu, Q.H. Shen, L.F. Chen, W.H. You, X.M. Wang and J.S. Sheng, J. Mater. Chem. Vol. 22(2012), p.24132.

[7] L. Wang, Y.B. Li, Y. Zuo, L. Zhang, Q. Zou, L. Cheng and H. Jiang, Biomed. Mater. Vol. 4 (2009).

[8] L.M. Li, Y. Zuo, J.J. Du, J.D. Li, B. Sun and Y.B. Li, J. Inorg. Mater. Vol. 28(2013), p.811.

[9] H.H. Liu, L. Zhang, P.J. Shi, L. Wang, D. Huang, J. Shen, P.J. Shi and Y.B. Li, J. Biomed. Mater. Res B. Vol. 95B(2010), p.36.