Growth of Hydroxyapatite on Strontium Oxide Modified Bioactive Glass

Abstract:

The bioactive glasses of SiO₂-CaO-P₂O₅-SrO system have been prepared by a quick alkali mediated sol-gel method. The prepared bioactive glass of 1, 3, 5 wt% of SrO (coded: SR1, SR3, SR5, respectively) were characterized by SEM, XRD and FTIR. XRD pattern of all glasses calcined at 700°C in air confirmed that the calcined bioactive glass generally existed in amorphous state. The samples were immersed in simulated body fluid (SBF) to investigate the presence of hydroxyapatite (HA). All bioactive glass samples can induce the formation of hydroxyapatite (HA) as verified by SEM and XRD.

• Periodical: Advanced Materials Research (Volume 1107)
• Pages: 397-402
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.1107.397
• Online since: June 2015
• Authors: H.J.M. Ridzwan, N.H. Jamil, S.A. Syamsyir, W.A.W. Razali
• Keywords: Bioactive Glass, Hydroxyapatite (HA), Simulated Body Fluid, Strontium Oxide

References

[1] L.L. Hench, R.J. Splinter, W.C. Allen, & T.K. Greenle, Bonding mechanisms at the interface of ceramic prosthetic materials, Journal of Biomedical Materials Research. 5(6) (1971) 117-141.

DOI: 10.1002/jbm.820050611

[2] A. Lucas Girot, F.Z. Mezahi, M. Mami, H. Oudadesse,A. Harabi, & M.L. Floch, Sol-gel synthesis of a new composition of bioactive glass in the quartenary system SiO2-CaO-Na2O-P2O5 : Comparison with melting method, Journal of Non-Crystalline Solids. 357 (2011).

DOI: 10.1016/j.jnoncrysol.2011.06.002

[3] E. Gentleman, Y.C. Fredholm, G. Jell, N. Lotfibakhshaiesh, M.D. O'Donnell, R.G. Hill, & M.M. Stevens, The effects of strontium- substitute bioactive glasses on osteoblasts in vitro, Biomaterials. 31(1971) 3949-3956.

DOI: 10.1016/j.biomaterials.2010.01.121

[4] Q.Z. Chen, Y. Li, L.Y. Jin, J.M.W. Quinn, & P.A. Komesaroff, A new sol-gel process for producing Na2O-containing bioactive glass ceramics, Acta Biomaterialia. 6 (2010) 4143-4153.

DOI: 10.1016/j.actbio.2010.04.022

[5] W. Xia and J. Chang, Preparation and characterization of nano-bioactive glasses (NBG) by a quick alkali-mediated sol-gel method, Material Letter. 61 (2006) 3251-3253.

DOI: 10.1016/j.matlet.2006.11.048

[6] Z. Hong, A. Liu, L. Chen, X. Chen, and X. Jing, Preparation of bioactive glass ceramic nanoparticles by combination of sol-gel and coprecipitation method, Journal of Non-Crystalline Solids. 355 (2009) 368-372.

DOI: 10.1016/j.jnoncrysol.2008.12.003

[7] A.M. El-Kady, and A.F. Ali, Fabrication and Characterization of ZnO modified bioactive glass nanoparticles, Ceramics international. 38 (2011) 1195-1204.

DOI: 10.1016/j.ceramint.2011.07.069

[8] A. Goel, R.R. Rajagobal, & J.M.F. Ferreira, Influence of strontium on structure, sintering and biodegradation behavior of CaO–MgO–SrO–SiO2–P2O5–CaF2 glasses, Acta Biomaterialia. 7 (2011) 4071–4080.

DOI: 10.1016/j.actbio.2011.06.047

[9] H.F. Ko, Design, Synthesis, and Optimization of Nanostructured Calcium Phosphates (NanoCaPs) and Natural Polymer Based 3-D Non-viral Gene Delivery Systems, ProQuest LLC, Michigan, (2009).

[10] M.D. O'Donnell, P.L. Candarlioglu, C.A. Miller, E. Gentleman, & M.M. Stevens, Materials characterisation and cytotoxic assessment of strontium-substituted bioactive glasses for bone regeneration, Journal of Materials Chemistry. 20(40) (2010).

DOI: 10.1039/c0jm01139h

[11] L.L. Hench, Bioceramics –from concept to clinic, Journal of the American Ceramic Society. 74 (1991) 1487-1510.

DOI: 10.1111/j.1151-2916.1991.tb07132.x