An Improved Method for the Preparation for New Antibacterial Dressing Crosslinked with Carboxymethyl Chitosan

Qian Wang; Ke Gong; Cheng Bo Cao; Jing Guo; Xiao Jiao Wang

doi:10.4028/www.scientific.net/AMR.1145.39

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HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 1145An Improved Method for the Preparation for New...

An Improved Method for the Preparation for New Antibacterial Dressing Crosslinked with Carboxymethyl Chitosan

Abstract:

A new antibacterial acellular dermal matrix (AADM) dressing can not only resist infection, but also accelerate wound healing. AADM was prepared by SDS (0.40%), trypsin (0.40%) and keratin (0.30%), and then cross-linked with carboxymethyl chitosan (1%) with glutaraldehyde, whose tensile strength (MPa) is 10.66, thickness (mm), 0.53, the rate of permeable steam (g • m^-2 • 24h^-1), 3640, porosity (%), 81, degradation time in vitro (h), 24.33, pH, 6.5, and the average inhibition rate, more than 70%. At the same time, scanning electron microscopy showed that the structure of AADM was evacuated and the pores were interconnected. On such basis, a conclusion was drawn: the properties of AADM has been sharply increased, compared with acellular dermal matrix, which cannot resist infection, and the new antibacterial acellular dermal matrix completely meets the clinical requirements for burn dressings.

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Periodical:

Advanced Materials Research (Volume 1145)

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39-43

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https://doi.org/10.4028/www.scientific.net/AMR.1145.39

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Online since:

March 2018

Authors:

Qian Wang, Ke Gong, Cheng Bo Cao, Jing Guo, Xiao Jiao Wang

Keywords:

Acellular Dermal Matrix, Antibacterial, Carboxymethyl Chitosan, Dressing

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