Considering the requirement of the multi-parameter-combined environment testing device, a kind of multi-parameter measure and control system based on wireless communication technology was studied in this paper. First, the overall structure of the multi-parameter measure and control system based on wireless communication in combined environment device was put forward, which was made up of six control subsystems: a host computer, the centrifuge and dynamic balance system, the vibration and rectification system, the temperature system, the air pressure system and the sound pressure system. Then, the communication protocol and hardware structure of the multi-computer communication system based on wireless transmission were mainly studied. And software design technology of multi-parameter measure and control system was studied in succession. Finally, the five-parameter-combined environment testing was carried out. The experimental results show that the measure and control tasks of the combined environment testing can be well finished by the multi-parameter measure and control system.