The strength and the fouling resistance of PVDF membrane prepared by wet phase inversion process can be improved by an innovation in membrane preparation. The prepared flat-sheet PVDF-fabric composite membrane consists of a fabric layer and a PVDF membrane layer. The fouling resistance of the composite membrane in membrane distillation (MD) desalination was investigated by air gap membrane distillation (AGMD), using simulated saline water and high concentration NaCl solution as the feed solutions respectively. The experimental results showed that the water-and-oil repellent finishing of the fabric support had a significant effect on the bonding strength and the fouling resistance of the composite membrane. With the protection of the fabric layer for the PVDF membrane layer, the composite membrane exhibited better fouling resistance as its fabric surface was in contact with the feed solution in MD process, when the fabric support was finished with 2g/L FK-501.