Study on the Supramolecular Interaction of Curcumin and RM-β-CD-m

Abstract:

The supramolecular interaction of curcumin and RM-β-CD-m was studied by spectrophotometry, and the apparent formation constant for curcumin-RM-β-CD-m complex was determined. The results showed that a 1:1 complex between curcumin and RM-β-CD-m was formed, and the apparent formation constants increase with the increase of reaction temperature. The thermodynamic parameters, standard free energy (ΔG°), enthalpy (ΔH°) and entropy (ΔS°) for complex formation of curcumin with RM-β-CD-m were calculated. ΔG° value indicates that the complex formation is a spontaneous, endothermic process, and the main driving force for complex formation is entropy. The inclusion complex was confirmed by infrared spectrum (IR).

• Periodical: Advanced Materials Research (Volumes 152-153)
• Pages: 1377-1381
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.152-153.1377
• Online since: October 2010
• Authors: Chun Tao Kuang, Xiang Zhou Li, Ye Wang, Yi Chang He, Yuan Liang Guo
• Keywords: Apparent Formation Constant, Curcumin, Inclusion Complex, RM-β-CD-m, Spectrophotometry, Thermodynamic Parameters

References

[1] A.K. Tuka and I Gülcin. Chem. Biol. Interact. Vol. 174(2008), pp.27-37.

[2] W.F. Chen, S.L. Deng, B. Zhou, L. Yang and Z. L Liu. Free Radical Biol. Med. Vol. 40(2006), pp.526-535.

[3] A. Mukhopadhyaya, N. Basu and N. Ghatak. Agents and Actions Vol. 12(1982), pp.508-515.

[4] S. Chuang, A. Cheng, J. Lin and M. Kuo. Food Chem. Toxicol. Vol. 38(2000), pp.991-995.

[5] G.K. Jayaprakasha, L. Jagan Mohan Rao and K.K. Sakariah. Trends Food Sci. Tech. Vol. 16 (2005), pp.533-548.

DOI: 10.1016/j.tifs.2005.08.006

[6] D. Eigner and D. Scholz. J. Ethnopharmacol. Vol. 67(1999), pp.1-6.

[7] A.J. Ruby; G. Kuttan, K.D. Babu, K.N. Rajasekharan and R. Kuttan. Cancer Lett. Vol. 94(1995), pp.79-83.

DOI: 10.1016/0304-3835(95)03827-j

[8] K. Polasa, A.N. Naidu, I. Ravindranath and K. Krishnaswamy. Mutation Reasearch. Vol. 557 (2004), pp.203-213.

[9] V. Ravindranath, N. Chandrasekhara. Toxicology Vol. 22(1982), pp.337-344.

[10] H.H. Tønnesen and J. Karlsen. Z. Lebensm. - Unters. Forsch Vol 180 (1985), pp.402-404.

[11] H.H. Tønnesen and J. Karlsen. Z. Lebensm. -Unters. Forsch Vol 180(1985), pp.132-134.

[12] H.H. Tønnesen, J. Karlsen and G. Beijersbergen van Henegouwen. Z. Lebensm. -Unters. Forsch. Vol 183(1986), pp.116-122.

[13] B. Tang, L. Ma, H.Y. Wang and G.Y. Zhang. J. Agric. Food. Chem. Vol. 50(2002), pp.1355-1361.

[14] H.H. Tønnesen, M. Másson and T Loftsson. Int. J. Pharm. Vol. 244(2002), pp.127-135.

[15] M.A. Tomren, M. Másson T. Loftsson and H. H. Tønnesen. Int. J. Pharm. Vol. 338(2007), pp.27-34.

[16] V.J. Stella and R.A. Rajewski. Pharm. Res. Vol. 14(1997), pp.556-567.

[17] A. D. Qi, L. Li and Y. Liu. J Chin. Pharmaceu. Sci. Vol. 12(2003), pp.15-20.

[18] C. T Kuang, X. Z Li, H.P. Xue, Q. Su and Y.L. Guo. in: Proceedings of 2009 International Conference of Natural Products and Traditional Medicine edited by Springer-Verlag, NY(2009).

[19] K.N. Baglole, P.G. Boland and B.D. Wagner. J. Photochem. Photobiol. Vol. 173(2005), pp.230-237.