Study on the Supramolecular Interaction of Curcumin and RM-β-CD-m
The supramolecular interaction of curcumin and RM-β-CD-m was studied by spectrophotometry, and the apparent formation constant for curcumin-RM-β-CD-m complex was determined. The results showed that a 1:1 complex between curcumin and RM-β-CD-m was formed, and the apparent formation constants increase with the increase of reaction temperature. The thermodynamic parameters, standard free energy (ΔG°), enthalpy (ΔH°) and entropy (ΔS°) for complex formation of curcumin with RM-β-CD-m were calculated. ΔG° value indicates that the complex formation is a spontaneous, endothermic process, and the main driving force for complex formation is entropy. The inclusion complex was confirmed by infrared spectrum (IR).
Zhengyi Jiang, Jingtao Han and Xianghua Liu
C. T. Kuang et al., "Study on the Supramolecular Interaction of Curcumin and RM-β-CD-m", Advanced Materials Research, Vols. 152-153, pp. 1377-1381, 2011