Failures in concrete elements and structures often result from simultaneous effect of heat and moisture in concrete or form environment. Numerical simulation is an efficient way for investigating concrete deformation and the thermal and moisture parameters are the essential inputting data in simulation. Obviously, the numerical deformation of concrete will change with the varying thermal or moisture parameters which result from the materials and mix ratio used in preparing the concrete. The influences of hygro-thermal physical parameters on the deformation of concrete were investigated numerically using a specially developed software, which is named Coupling Temperature and Moisture Simulation System for concrete (CTMSoft) in this paper. The results of numerical experiment imply that evaluating the influence regularity of only a single parameter on the concrete deformation is unscientific and the coupling effect should be considered in the fact that there is not a definite relationship between concrete deformation and a single parameter.