Prediction of Antigenic Epitopes for Coat Protein of Potato virus Y

Shi Hui Guo; Chun Lei Wang; Hong Yi Yang; Na Na Zhang; Xin Zhuang; Dai Zong Cui

doi:10.4028/www.scientific.net/AMR.183-185.1204

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Prediction of Antigenic Epitopes for Coat Protein of Potato virus Y
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HomeAdvanced Materials ResearchAdvanced Materials Research Vols. 183-185Prediction of Antigenic Epitopes for Coat Protein...

Prediction of Antigenic Epitopes for Coat Protein of Potato virus Y

Abstract:

Potato virus Y (PVY) is one of the most important viruses that infect Solanaceous crops. In the study, the antigenic epitopes were predicted using computer-assisted analysis, and many potential regions of antigenic epitopes were located. Many properties of coat protein, such as the antigenic index, α-helix, β-sheet, β-turn, coil structure, hydrophilicity, surface probability, and flexibility, were analyzed with several algorithms in some softwares. Based on the rules for location the antigenic epitopes in the regions including β-turns and coil structures with the high hydrophilicity and surface probability, the predicted epitopes were located in the region of amino acid position 8-22, 24-38, 45-55, 240-255, respectively. It is helpful to prepare the antiserum of PVY based on the prediction result of antigenic epitope.