Prediction of Antigenic Epitopes for Coat Protein of Potato virus Y
Potato virus Y (PVY) is one of the most important viruses that infect Solanaceous crops. In the study, the antigenic epitopes were predicted using computer-assisted analysis, and many potential regions of antigenic epitopes were located. Many properties of coat protein, such as the antigenic index, α-helix, β-sheet, β-turn, coil structure, hydrophilicity, surface probability, and flexibility, were analyzed with several algorithms in some softwares. Based on the rules for location the antigenic epitopes in the regions including β-turns and coil structures with the high hydrophilicity and surface probability, the predicted epitopes were located in the region of amino acid position 8-22, 24-38, 45-55, 240-255, respectively. It is helpful to prepare the antiserum of PVY based on the prediction result of antigenic epitope.
Yanguo Shi and Jinlong Zuo
S. H. Guo et al., "Prediction of Antigenic Epitopes for Coat Protein of Potato virus Y", Advanced Materials Research, Vols. 183-185, pp. 1204-1208, 2011