The Synthesis of Mg-Zn-Al LDH and the Sustained-Release Properties of Theophylline Intercalated LDH

Abstract:

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Layered double hydroxides (LDHs), consist of cationic brucite-like layers and exchangeable interlayer anions. In this thesis LDHs consist of brucite-like layers of zinc hydroxide, with the exchanging propertity of interlayer anions in hydrotalcites, used Mg/Zn/Al-LDH as precursor to prepare the theophylline intercalation assembly hydrotalcites to obtain supramolecular complex for the first time by co-precipitation under a nitrogen atmosphere, determined the reaction conditions and influential factors of the synthesis of theophylline-pillared hydrotalcites, and tested its sustained-release performance in different media. The product has been characterized by powder X-ray diffraction (XRD), FT-IR spectroscopy, uv-vis spectrophotometer and thermogravimetry-Differential thermal analysis (TG-DTA) . Results demonstrated that : Through co-precipitation intercalation methods, with molar ratio of Mg/Zn/Al/ theophylline being 3:1:1:2, co-precipitation medium pH9, crystallization temperature 80 °C and crystallization time 12h can obtain the clear chemical composition and good crystallization of inorganic - organic hybrid-type drugs hydrotalcites. In addition, according to Pharmacopoeia measured the release rate of theophylline-LDH in the different media including distilled water,0.9%saline,simulated intestinal fluid (pH7.4 phosphate buffer) by UV spectrophotometry, Theophylline pillared hydrotalcite has a certain release in the media above all. And calculated the release of intercalation theophylline, lay the foundation for the further clinical application.

Info:

Periodical:

Advanced Materials Research (Volumes 189-193)

Edited by:

Zhengyi Jiang, Shanqing Li, Jianmin Zeng, Xiaoping Liao and Daoguo Yang

Pages:

2448-2455

DOI:

10.4028/www.scientific.net/AMR.189-193.2448

Citation:

B. Z. Du et al., "The Synthesis of Mg-Zn-Al LDH and the Sustained-Release Properties of Theophylline Intercalated LDH", Advanced Materials Research, Vols. 189-193, pp. 2448-2455, 2011

Online since:

February 2011

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Price:

$35.00

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