An impeller is the core of aviation engine components, the processing quality has a decisive impact on the performance of the engine. An impeller is also one of the most important basic components of centrifugal compressor. When a three-axis CNC machining centre is used for producing an impeller, great difficulties, i.e. collisions between the cutting tool and the impeller, can occur. As the surface is normally twisted in design to achieve the required performance, it can cause overcut and collision problems during machining. To solve these problems, an integrated five-axis machining approach for a centrifugal impeller by combining related machining technologies is developed. As a result, Cutter Location data based on the geometry model of blade and hub of the impeller are generated. Finally, the Cutter Location data is verified through software simulation. The results prove that the machining methodology adopted is useful and efficient.