MoS2 with rose-like morphology have been successfully synthesized using by an ionic liquid-directed hydrothermal synthesis. XRD results showed that the as-prepared MoS2 directed by ionic liquid Brij56 have the good peaks. SEM images revealed that the MoS2 nanoflowers had rose-like morphology composed of many stacked sheets. TEM images showed that MoS2 nanoflowers have incompactly petal-like stacked structure. These results showed that ionic liquid Brij56 could effectively influence the morphology of MoS2. Ionic liquid played a crucial role as a structure-directed reagent in the formation of MoS2 nanoflowers and the possible growth mechanism of MoS2 nanoflowers was also discussed.