Based on the high temperature compression simulation experiments, the mechanical behavior of Ti-6AI-2Zr-1Mo-1V alloy were studied over the range of temperature from 850°C to 1100°C , strain rate from 0.01 to 10s-1. The results show that the flow stress reduces with temperature increasing at the constant strain rate and increases rapidly with strain rate increasing at the constant temperature. The stress index n and deformation activation energy Q is respectively 7.0874 and 610.463 kJ/mol at 850-950°C . While at 950-1100°C , n is 4.7324 and Q is 238.030 kJ/mol. From the obtained processing map, it is found that two unstable regions present at the lower temperature or higher strain rate and two optimum regions in hot deformation process. The unstable zones are 850-950°C , 0.001-0.008s-1 of strain rate, and 940-1030°C , 2-10s-1 of strain rate respectively. In the optimum zone with the temperature range of 1060-1100°C , strain rate of 0.05-0.65s-1, and the peak efficiency of power dissipation of about 0.42; while in the other zone with the deformation temperature 890-940°C , strain rate of 0.06-0.18s-1, and the peak efficiency of power dissipation of about 0.33.