Biomechanical Numerical Simulation of Bone Tissue Engineering Scaffolds

Abstract:

Biomechanical compatibility is one of the key targets for bone tissue engineering scaffolds. As the repair of hard tissue, the scaffold should be of similar strength and elasticity modulus with replaced bone to avoid stress shielding. This paper combines the finite element method and the computer simulation technology analyzing the stress influence of the porous β-TCP scaffold and the middle of femur in different internal architectures, and the simulation results show that scaffold implants at lower porosity conducive to the elimination of stress shielding. The aim of this paper is to provide the theory and design basis on the bone tissue engineering scaffolds.

• Periodical: Advanced Materials Research (Volume 213)
• Pages: 306-310
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.213.306
• Online since: February 2011
• Authors: Liu Lan Lin, Wen Juan Wang, Jia Feng Zhang, Ming Lun Fang
• Keywords: Biomechanics, Bone Tissue Engineering Scaffold, Finite Element Model (FEM), Stress Shielding

References

[1] Wang YL, Cai SZ: Biomechanics and bone tissue engineering. Advances in Mechanics, Vol. 29(2) (1999), p.232.

[2] Hutmacher D.W.: Scaffolds in tissue engineering bone and cartilage. Biomaterials, Vol. 21 (2000), p.2529.

DOI: 10.1016/s0142-9612(00)00121-6

[3] Ye JZ, Zhang CQ, Men YT, etal: The research of numerical simulation method on bone injury, healing and stress shielding. Proceedings of Tianjin Society of Biochemical Engineering Annual Meeting (2007), p.60.

[4] Sandino C, Planel J.A., Lacroix D: A finite element study of mechanical stimuli in scaffolds for bone tissue engineering. Journal of Biomechanics, 41(5) (2008), p.1005.

DOI: 10.1016/j.jbiomech.2007.12.011

[5] Byrne D.P., Lacroix D, Planell J.A., etal: Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus and dissolution rate: Application of mechanobiological models in tissue engineering. Biomaterials, 28 (2007).

DOI: 10.1016/j.biomaterials.2007.09.003

[6] Porter N.L., Pilliar R.M., Grynpas M.D.: Fabrication of porous calcium polyphosphate implants by solid freeform fabrication: A study of processing parameters and in vitro degradation characteristics. Journal of Biomedical Materials Research, 56(4) (2001).

DOI: 10.1002/1097-4636(20010915)56:4<504::aid-jbm1122>3.0.co;2-j

[7] Bai XF, Zhu D, Zhang CQ: Structural simulation of proximal femur. Natural Science Journal of Jilin University of Technology, 30(4) (2000), p.56.

[8] Gao YL: Simulation analysis of stress in bone and implanted hydroxyapatite using finite element method (Master). Tianjin. Tianjin University (2005): 53-62.

[9] Ke H, Ning CQ, Jia DC, etal: Development of hydroxyapatite and titanium as bone substitute materials. NONFERROUS METALS, 53(4) (2001) p.8.

[10] Yao J, Turteltaub S.R., Ducheyne P: A three-dimensional nonlinear finite element analysis of the mechanical behavior of tissue engineered intervertebral discs under complex loads. Biomaterials, 27(3) (2006) p.377.

DOI: 10.1016/j.biomaterials.2005.06.036

[11] Wolff J.L.: The law of hone remodeling (Trans Springer, Berlin 1892).