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Computer-Aided Design and Fabrication of Bio-Mimetic Materials and Scaffold Micro-Structures

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Abstract:

Computer-aided design (CAD) has proven effective in enabling novel approaches for tissue engineering applications. This paper demonstrates the applicability of various mathematical methods to design and fabricate bio-mimetic materials via two illustrative examples. Firstly, CAD models of cellular biomaterials that mimic the micro-structure of cuttlefish bone are designed based on the principles of the homogenization method. Secondly, a three-dimensional bi-objective topology optimization approach based upon the inverse homogenization method is used to design scaffold micro-structures with tailored effective stiffness and permeability properties. Consequently, solid free-form fabrication is used to fabricate such cellular bio-mimetic materials, which show a great potential in tissue engineering applications.

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Advanced Materials Research (ICAMR) View Preview

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Periodical:

Advanced Materials Research (Volume 213)

Pages:

628-632

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.213.628

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Online since:

February 2011

Authors:

Yu Hang Chen, Joseph Cadman, Shi Wei Zhou, Qing Li

Keywords:

Bio-Mimetic Materials, Computer Aided Design (CAD), Homogenization Method, Scaffold, Solid Free-Form Fabrication (SFF), Tissue Engineering

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© 2011 Trans Tech Publications Ltd. All Rights Reserved

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