Trust problem of medical consumables supply chain has been increasingly a focus of people’s attention. Business competition based on reputation management becomes the new strategy for business development in medical consumables supply chain. The reputation relationships among entities are dynamic. The medical consumables supply reputation management involves many different elements: the collaboration among entities, collection of the information to assess the reputation, and the standards for reputation assessment. The design factors are found for consideration of medical consumables supply reputation evaluation and the reputation mechanism is designed on the basis of fuzzy clustering.