In this paper, the design and optimization procedures of a heterogeneous heat integrated azeotropic distillation sequence with side stripper (HIADS-SS) for the purification of isopropanol are investigated. The proposed procedures can detect the optimal values of the design variables and thereby guarantee the minimum energy consumption. The procedures are applied to the study of the separation of azeotropic mixtures using the two distillation sequences. In the HIADS-SS, the top end of the side stripper has both liquid and vapor exchange with the main column, which eliminates a condenser compared with the conventional heterogeneous azeotropic distillation sequence (CHADS). The results show that reductions in energy consumption can be obtained using the HIADS-SS.