Preparation and Characterization of Satraplatin - A New Bioactivity Material

Abstract:

Satraplatin is a platinum coordination with antitumour activity, which is the first platinum-based antitumour drug administrated by oral route. The phase III clinical trial used in the treatment of patients with hormone-refractory prostate cancer of Ssatraplatin has been finished. Its prepararation method was introduced in this paper, and its chemical structure was identified by using the modern apparatus analysis means such as elemental analyses, mass spectrum, infrared spectrum and nuclear magnetic resonance spectrum. The results showed that its composition and structure were consistent with the theoretical one

• Periodical: Advanced Materials Research (Volumes 233-235)
• Pages: 1192-1197
• DOI: https://doi.org/10.4028/www.scientific.net/AMR.233-235.1192
• Online since: May 2011
• Authors: Shao Ping Pu, Yan Wei Cong, Wen Gui Gao, Jin Hu, Qing Kun Wang, Jia Lin Sun
• Keywords: Characterization, Chemical Structure, New Antitumour Drug, Preparation, Satraplatin

References

[1] Giandomenico CM,Abrame MJ,Murrer BA,et al. Inorgchem. Vol.34(1995), pp.1015-1021.

[2] Shaoping Pu, Yu Yao, Wengui Gao, et al. : Purification of Satraplatin, Chinese patent, Patent NO. ZL 2004 1 0021818.8. (In Chinese)

[3] Neidle S, Snook C F, Murrer B A, et al. : Act. Cryst Sect. C, Vol.51(1995), pp.822-824