Inhibition of Proliferation and Induction of Apoptosis of HT-29 Colorectal Adenocarcinoma Cells in Vitro by Anthocyanins from Lonicera Edulis

Abstract:

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Anthocyanins was known for their antioxidant and pharmacological properties used by humans for therapeutic purposes. Here, we study the inhibitory effects of anthocyanins from Lonicera edulis on the proliferation of HT-29 colorectal adenocarcinoma cells and its possible mechanism in vivo by MTT. The different percentages of apoptotic cells present in flow cytometry analysis. The effect on HT29 cells was enhanced with increasing amount of anthocyanins. Typical morphological features of apoptosis were observed by transmission electron microscope. The mechanism of anthocyanins from Lonicera edulis on HT29 cell growth inhibition may be related to the induction of apoptosis.

Info:

Periodical:

Advanced Materials Research (Volumes 233-235)

Edited by:

Zhong Cao, Lixian Sun, Xueqiang Cao, Yinghe He

Pages:

2945-2948

DOI:

10.4028/www.scientific.net/AMR.233-235.2945

Citation:

Y. H. Bao et al., "Inhibition of Proliferation and Induction of Apoptosis of HT-29 Colorectal Adenocarcinoma Cells in Vitro by Anthocyanins from Lonicera Edulis", Advanced Materials Research, Vols. 233-235, pp. 2945-2948, 2011

Online since:

May 2011

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$35.00

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