Numerical analysis of thermal response and structural response of a suspended pre-stressed steel reticulated lattice shell are conducted for the key nodes of the structure of a gymnasium on software FDS. Two different location of fire source are considered for analysis of response displacements and stresses of the nodes of the pre-stressed lattice shell and three cables. It is shown that the response temperatures of three cables set in the structure have similar variation trend for the fire scene presented here and the fire temperature near inner cable is highest among the three cables. It is concluded that the shell element of center of the structure has largest response stress, and the element above the side cable has larger stress than the shell element above the middle cable when the fire source is located at center of the gymnasium. It is shown that decrease of the pre-stress of the outer cable far away from the fire source is smallest among the three cables set in the structure.