This paper presents a bidirectional piezoelectric actuator, which can be used to vibration control of serially connected isolation System. Firstly, the performance test of this control device was processed. Then vibration control experiment of serially connected isolation system with this control device based on sweep sine shaking table was carried out. The experimental results show that this control device has stable mechanical properties, produces semi-active control force fast and has the outstanding control efficiency for serially connected isolation system. In addition, this control still has the satisfactory control efficiency when the piezoelectric actuator of this control is failed, which indicates the fail-safe function of this control.