Synthesis and Safety Evaluation of a New Enteric Coating Material

Abstract:

Article Preview

A series of styrene-maleic anhydride (SMA)-ethanol polymers with different degree of esterification (DE) were synthesized, they had different pH-sensitive values and could be used as enteric coating materials. SMA-ethanol (DE50%) was used as the model compound to evaluate the safety as an enteric coating material, the results of acute toxicity tests showed that there was no acute toxicity. The reaction condition such as catalysts, catalyst amount, reaction time and temperature were also evaluated, the results indicated that the triethylamine (TEA) was the optimal catalyst, when methyl ethyl ketone (MEK) was the solvent, the catalyst amount was 15-20%(molar percent), the reaction at 80 OC for 8h could gain the highest conversation.

Info:

Periodical:

Edited by:

Deliang Chen

Pages:

157-160

DOI:

10.4028/www.scientific.net/AMR.266.157

Citation:

X. L. Lai et al., "Synthesis and Safety Evaluation of a New Enteric Coating Material", Advanced Materials Research, Vol. 266, pp. 157-160, 2011

Online since:

June 2011

Export:

Price:

$35.00

In order to see related information, you need to Login.