Application of ICA-CMAC in the Prediction of Human Hepatic Clearance

Abstract:

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In this paper, a novel improved Credit Assigned CMAC (ICA-CMAC) is designed based on the concept of credit to enhance the performance of the traditional CMAC. Then ICA-CMAC is used to predict the human hepatic clearance according to in-vitro data of drugs. The experiment results show that the prediction by ICA-CMAC is faster and more accurate and can be thought as a new and effective way for drug metabolism prediction.

Info:

Periodical:

Advanced Materials Research (Volumes 268-270)

Edited by:

Feng Xiong

Pages:

1759-1762

DOI:

10.4028/www.scientific.net/AMR.268-270.1759

Citation:

Y. Q. Ge et al., "Application of ICA-CMAC in the Prediction of Human Hepatic Clearance", Advanced Materials Research, Vols. 268-270, pp. 1759-1762, 2011

Online since:

July 2011

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Price:

$35.00

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