The classifier, built from a highly-skewed class distribution data set, generally predicts an unknown sample as the majority class much more frequently than the minority class. This is due to the fact that the aim of classifier is designed to get the highest classification accuracy. We compare three classification methods dealing with the data sets in which class distribution is imbalanced and has non-uniform misclassification cost, namely cost-sensitive learning method whose misclassification cost is embedded in the algorithm, over-sampling method and under-sampling method. In this paper, we compare these three methods to determine which one will produce the best overall classification under any circumstance. We have the following conclusion: 1. Cost-sensitive learning is suitable for the classification of imbalanced dataset. It outperforms sampling methods overall, and is more stable than sampling methods except the condition that data set is quite small. 2. If the dataset is highly skewed or quite small, over-sampling methods may be better.