The physicochemical properties of iron ore with arsenic in South of China was analyzed by chemical analysis, XRD, high power microscope. The effects of various factors on arsenic removal in sintering process were studied and the optimal technique parameters were obtained. The results show that the mineral of iron ore with arsenic in South of China mainly is composed of magnetite and gangue, in which arsenic with 0.282% mass content exists as FeAsS and few as As2S3. The oxidation and thermal decomposition reaction of FeAsS occurs in sintering process. Under feeble oxidation atmosphere the arsenic removal rate of iron ore along with reaction temperature increases, and the holding time elongates, or the coke powder content rises. The optimal removal arsenic process parameter is: reaction temperature 1050~1100°C, holding time 8~15min, and coke powder content 6%.