Heat conduction in anisotropic materials is quite different from that in isotropic materials. Heat flux vector is commonly not perpendicular to the isothermal surface in anisotropic materials. The advantage and disadvantage of anisotropic materials were analyzed in this paper. The thermal conductivities at one point are not equal in all directions for anisotropic materials. The technique of double skin facade has been successfully applied in many building designs. The application of combining building envelope of anisotropic materials and double skin facade was proposed to avoid its disadvantage. Basing on the combination of anisotropic materials and double skin facade in building envelope, the indoor cooling and heating load decrease in summer and winter respectively. Especially in summer, the effect of energy saving is obvious since the partial magnitude of conductive heat in the envelope made of anisotropic materials could be brought out from the cavity of double skin facade by natural or forced ventilation through it.